"Metabolite Profiling Applications of Mass Spectrometry at the Lead Optimization Stage"
Hesham Ghobarah,
Senior Applications Scientist
Life Technologies
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Abstract: This session will provide an overview of how the AB SCIEX QTRAP® 5500 hybrid triple quadrupole – linear ion trap system can be used to perform metabolite profiling studies in a highly innovative and productive manner. Two application areas of direct relevance to lead optimization will be discussed: Metabolic “soft spot” analysis for improving ADME properties, and in vitro screening for reactive metabolites.
Presenter Biography: Hesham Ghobarah is a senior applications specialist with Applied Biosystems. He specializes in field support for small molecule research applications involving triple quadrupole and ion trap LC/MS/MS systems. Prior to joining Applied Biosystems, Hesham worked in the pharmaceutical industry as a bioanalytical DMPK scientist. His current research interests include metabolite profiling, new approaches to quantitative bioanalysis, and the application of mass spectrometry to clinical diagnostics research.
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