Changing decision-making in life sciences & personalized medicine: Applied Semantic Knowledgebases (ASK ®) at work!
Erich Gombocz,
Vice President, Chief Scientific Officer
IO Informatics
|
|
Abstract: Building on advanced data access and integration capabilities, Sentient applies semantic patterns to create predictive network models using virtually any combination of internal experimental data and / or external published information. These patterns apply semantic SPARQL query technology to build complex searches across multiple information sets. SPARQL is a semantic search technology capable of detecting patterns within and between different data types and relationships, even if the initial datasets are not formally joined under any common database schema or data federation method. Such patterns or models are then placed in an Applied Semantic Knowledgebase (ASK) which is unique to a specific research focus, providing a collection of specific models applicable to screening and decision making. Such applications include target profile creation and validation, compound efficacy and promiscuity screening, toxicity profiling and detection, disease signatures, predictive clinical trials pre-screening, and patient stratification.
On the example of applying this technology to predictive toxicology using combinatorial biomarkers to categorize treatment-specific responses involving a set of very different biological functions, the power of ASK is demonstrated. Insights gained from semantically joining coherent findings despite their different methodologies allow researchers to better understand how the organism responds to experiment-induced system changes and to recognize mechanistic aspects of toxicity biomarkers at a functional level.
Using ASK makes it possible to actively screen previously disconnected, distributed datasets, to identify and stratify results - delivering applications to be used for decision making in the life science industry and in personalized medicine.
Presenter Biography: Dr. Erich Gombocz has over 25 years of experience in Life Science research, laboratory automation and data management in scientific and distributed systems environments, plus more than 20 years programming experience in instrumentation control, user interface, database design, scientific analysis, and on-line laboratory automation as well as being developer of innovative software algorithms and architecture.
Focusing on semantic data integration and knowledge management in life sciences, he founded IO Informatics in 2003 together with Bob Stanley to apply systems biology approaches to challenges in the area of pharmaceutical and clinical decision-making.
Dr. Gombocz has published over 60 scientific publications and holds currently more than 40 biotechnology- and software-related US and international patents. He is an international expert in separation science and bioinformatics, a member of several professional organizations, and serves on the editorial board of a number of scientific journals.
Online Presentation: http://lifescience.planetconnect.com/ppt/PMPrinceton/ERICH_GOMBOCZ.ppt
|
